Understanding the healing Properties of Aloe and its constituents…

Aloe Vera

· Aloe Vera is an amazing mixture of more than 200 constituents, including polysaccharides, enzymes, glycoproteins, amino acids, vitamins and minerals.

· The active polysaccharide fractions in aloe are called galacto-mannans or beta-glucomannans

What is Acemannan?

· Wikipedia defines acemannan as “Acemannan is a D-isomer mucopolysaccharide in aloe vera leaves. This compound has been known to have immunostimulant, [1] antiviral, antineoplastic and gastrointestinal properties. [2]

· Acemannan (the name often used for aloe beta-glucomannans, acetylated polymannans and mucopolysaccharides) is a long chain sugar that interjects itself into all cell membranes.

Why Now?

· Traditionally, the problem with aloe vera products is that the key active ingredients, the mannan sugars, are not particularly concentrated in the aloe plant.

· Additionally they are not particularly stable. In addition, they are easily destroyed both in the harvesting process and in the concentration process.

· A new patented aloe process allows for the supreme preservation of the acemannan and other polysaccharides at a level never seen before!

How does the body use it.

· Mannose is very important in cellular communication and glycoprotein synthesis.

· Glucose can be converted to mannose by enzymes if not enough ingested.

· Always assumed that glycoprotein biosynthesis was derived entirely from glucose. “Monosaccharides are an alphabet of coding capacity like amino acids and nucleic acids…mannose being one of the most important” (Journal of Glycobiology, 98)

How does the body get Acemannan?

· Bacteria in small intestine breaks down the polysaccharides then you have pumps that push the mannose into the bloodstream.

· Glucose can be converted to mannose by enzymes if not enough ingested on surface of cells, macrophages they have receptors that look for mannose and other mono saccharides, requires calcium to work.

· Mannose binding lectins

So What does Acemannan do exactly?

· These polysaccharides have been shown in laboratory studies to act as a bridge between foreign proteins (such as virus particles) and macrophage cells in the human body, facilitating the destruction of the invading protein by the macrophage.

· Activating the receptor sites of the macrophages is also a key to the overall boosting of cell-mediated immunity, which, significantly, is deficient in HIV infection and other immune disorders.

· Aloe polysaccharides also protect the bone marrow from damage by toxic chemicals and drugs.

Let’s See Some Science!

· “In-vivo results showed acemannan-treated groups had higher bone mineral density and faster bone healing compared with untreated controls. A substantial ingrowth of bone trabeculae was observed in acemannan-treated groups. These data suggest acemannan could function as a bioactive molecule inducing bone formation by stimulating BMSCs proliferation, differentiation into osteoblasts, and extracellular matrix synthesis” (Jittapiromsak et al, 2010).

· Arch Pharm Res. 2010 Mar;33(3):451-6.doi: 10.1007/s12272-010-0315-1.Epub 2010 Mar 30.

· In vivo evidence of the immunomodulatory activity of orally administered Aloe Vera gel.

· Im SA, Lee YR, Lee YH, Lee MK, Park YI, Lee S, Kim K, Lee CK.

· College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.

· Immunopharmacology. 1996 Nov;35(2):119-28

· Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe Vera Gel.

· Zhang L, Tizard IR

· Department of Veterinary Pathobiology, Texas A&M University College Station 77843,USA.

Results:

· The percentage of both objective tumor regressions and disease control was significantly higher in patients concomitantly treated with Aloe than with chemotherapy alone, as well as the percent of 3-year survival patients.

Conclusion:

· This study seems to suggest that Aloe may be successfully associated with chemotherapy to increase its efficacy in terms of both tumor regression rate and survival time. (Lissoni et al, 2009).

What’s the take home?

· Acemannan interjects itself into all cell membranes. This results in an increase in the fluidity and permeability of the membranes allowing toxins to flow out of the cell more easily and nutrients to enter the cell more easily.

· The bottom line is that concentrated aloe fractions enhance the functioning of the entire immune system, detoxify the body, promote the repair of a wide range of tissues and organs, improve digestive functions, and help with the destruction and elimination of invading bacteria, viruses, and parasites.

· Increase the body’s own production of interferon, interleukins.

· Increase the number of antibody forming T-cells in the spleen.

· Great against pathogens on any mucous membrane.

Each capsule has a guaranteed 1/8th tsp of acemannan

• Helps strengthen immune system
• Helps clear viral infections
• Helps control mucous in the body
• Soothes entire digestive system
• Helps improve conditions for enhanced nutrient absorption

Grown in open sea air on a volcanic island in rich volcanic soil. As the aloe is harvested in the field, its inner leaf gel is manually separated from its outer sheath. It is then immediately centrifuged to eliminate the water content, then immediately freeze-dried – all right in the field. This rigorous method delivers the freshest richest concentration of acemannan possible.

Our delicate growing and processing delivers the highest amount of short-chain mannose sugars which are often deficient in other aloe products because the enzymes in the aloe can destroy the short chain mannose within hours of separation from the plant.

Acemannan

Mannose sugars include beta 1-4D, a key building block for the healthy cell. Acemannan is a D-isomer mucopolysaccharide in Aloe vera. Studies show acemannan has immunostimulant, antiviral, antineoplastic and gastrointestinal properties. Some evidence shows acemannan may reduce mycotoxic body burden. Acemannan has been demonstrated to induce macrophages to secrete interferon (INF), tumor necrosis factor – a (TNF-A) and interleukins (IL-1). This suggests it may help to prevent or clear viral infection. In vitro studies have shown acemannan to inhibit HIV replication. Acemannan is currently being used for treatment of fibrosarcoma in animals. QRA testing results of Aloe Mannan-FX shows great promise for all mucus membranes, especially the upper GI; therapy localize to test points, or test at Thymus.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 30

Organic Inner Leaf Aloe (Aloe barbadensis): 160mg

(Standardized to 15% acemannan, 24mg)

Calcium Bentonite: 57mg

Luo Han Guo Extract: 8mg

Other Ingredients: Marine Coral, Rice Protein, Vegetable Capsules

*These statements have not been evaluated by the food and drug administration, this product is not intended to diagnose, treat, cure or prevent disease